EASY-GOING DUMBO On-Spectrometer Optimisation of Phase Modulated Homonuclear Decoupling Sequences in Solid-State NMR,

D. L. A. G. Grimminck, S. K. Vasa, W. L. Meerts, A. P. M. Kentgens, and A. Brinkmann,
Chem. Phys. Lett. 509, 186-191, (2011).

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A one-​step many-​parameter optimisation scheme for phase modulated proton homonuclear decoupling sequences in solid-​state NMR is presented. Phase modulations, parameterised by DUMBO Fourier coefficients, were optimized using a Covariance Matrix Adaptation Evolution Strategies algorithm. Our method, denoted EASY-​GOING DUMBO, starts with featureless spectra and optimises proton-​proton decoupling, during either proton or carbon signal detection. Optimisations at moderate sample magic angle spinning (MAS) frequencies and medium radio-​frequency (rf) field strengths resulted in solutions closely resembling (e)DUMBO. Application of EASY-GOING DUMBO for optimisation at very high 680 kHz rf field strength, 12.5 kHz MAS on a 400 MHz NMR spectrometer resulted in a new solution, with competitively resolved proton spectra.

Dr. Andreas Brinkmann
NRC Metrology
National Research Council Canada
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